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Antidepressant medications - selective serotonin reuptake inhibitors (SSRIs)

Table of Contents > Depletions > Antidepressant medications - selective serotonin reuptake inhibitors (SSRIs)

	Selected Medications
	Depletions
	Editorial Note
	Supporting Research

Selected Medications

Fluoxetine
- Prozac
- Prozac Weekly
- Sarafem

Depletions

Melatonin

Reduced levels of melatonin in the body have been associated with sleep disturbances and jet lag.

Proteins and Amino Acids

Protein deficiencies are characterized by weakened immune status, including increased susceptibility to infection, impaired wound healing, muscle and weight loss, growth retardation, and deterioration in skin and hair condition.

Editorial Note

The selected depletions information presented here identifies some of the nutrients that may be depleted by certain medications. The signs and symptoms associated with nutrient deficiency may also indicate conditions other than nutrient deficiency. If you are experiencing any of the signs or symptoms mentioned, it does not necessarily mean that you are nutrient deficient. Nutrient depletion depends upon a number of factors, including your medical history, diet, and lifestyle as well as the length of time you have been taking the medication. Please consult your health care provider; he or she can best assess and address your individual health care needs, and determine if you are at risk for nutrient depletions from these medications as well as others not listed here.

Supporting Research

Acuna-Castroviejo D, Escames G, Rodriguez MI, Lopez LC. Melatonin role in the mitochondrial function. Front Biosci. 2007;12:947-63.

Altun A, Ugur-Altun B. Melatonin: therapeutic and clinical utilization. Int J Clin Pract. 2007;61(5):835-45.

Childs PA, Rodin I, Martin NJ, et al. Effect of fluoxetine on melatonin in patients with seasonal affective disorder and matched controls. Br J Psychiatry. 1995;166:196-198.

Lewy AJ, Emens J, Jackman A, Yuhas K. Circadian uses of melatonin in humans. Chronobiol Int. 2006;23(1-2):403-12.

Piccirillo JF. Melatonin. Prog Brain Res. 2007;166:331-3.

Powers HJ. Riboflavin (vitamin B-2) and health. Am J Clin Nutr. 2003;77(6):1352-60.

Reiter RJ. Melatonin: clinical relevance. Best Pract Res Clin Endocrinol Metab. 2003;17(2):273-85.

Urdaneta E, Idonte I, Larraldo J. Drug-nutrient interactions: inhibition of amino acid intestinal absorption by fluoxetine. Br J Nutr. 1998;79(5):439-446.

Review Date: 12/24/2007
Reviewed By: All depletions monographs have been reviewed by a team of experts including Ernest B. Hawkins, MS, BSPharm, RPh, Health Education Resources; Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network.

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