• Diclofenac
  • Cataflam Oral
  • Solaraze Topical
  • Voltaren Ophthalmic
  • Voltaren Oral
  • Voltaren-XR Oral
• Diflunisal
  • Dolobid
• Etodolac
  • Lodine
  • Lodine XL
• Fenoprofen
  • Nalfon
• Ibuprofen
  • Advil Migraine Liqui-Gels[OTC]
  • Advil[OTC]
  • Children's Advil Oral Suspension[OTC]
  • Children's Motrin Oral Suspension[OTC]
  • Genpril[OTC]
  • Haltran[OTC]
  • Junior Strength Motrin[OTC]
  • Menadol[OTC]
  • Midol IB[OTC]
  • Motrin
  • Motrin IB [OTC]
  • Motrin Migraine Pain[OTC]
  • Nuprin[OTC]
• Indomethacin
  • Indocin
• Ketoprofen
  • Actron[OTC]
  • Orudis
  • Orudis KT[OTC]
  • Oruvail
• Meclofenamate
  • Meclomen
• Nabumetone
  • Relafen
• Naproxen
  • Aleve[OTC]
  • Anaprox
  • EC Naprosyn
  • Naprelan
  • Naprosyn
• Oxaprozin
  • Daypro
• Piroxicam
  • Feldene
• Sulindac
  • Clinoril
• Tolmetin
  • Tolectin
  • Tolectin DS

Depleted levels of iron may lead to anemia and weakened immune function. In the event of anemia, symptoms include dizziness, fatigue, shortness of breath, pale skin color, and possibly irregular heartbeat.

Reduced levels of melatonin in the body have been associated with sleep disturbances and jet lag.

Low levels of folic acid have been linked to anemia, heart disease, and birth defects.

Signs and symptoms of zinc deficiency include loss of appetite or sense of taste, growth retardation, skin changes, and increased susceptibility to infection.

The selected depletions information presented here identifies some of the nutrients that may be depleted by certain medications. The signs and symptoms associated with nutrient deficiency may also indicate conditions other than nutrient deficiency. If you are experiencing any of the signs or symptoms mentioned, it does not necessarily mean that you are nutrient deficient. Nutrient depletion depends upon a number of factors, including your medical history, diet, and lifestyle as well as the length of time you have been taking the medication. Please consult your healthcare provider; he or she can best assess and address your individual healthcare needs, and determine if you are at risk for nutrient depletions from these medications as well as others not listed here.

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Baggott, JE, et al. Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs. Biochem. J. 282(Pt.I):197-202, 1992.

Elling H, Kiilerich S, Sabro J, Elling P. Influence of a non-steroid anti-rheumatic drug on serum and urinary zinc in healthy volunteers. Scand J Rheumatol. 1980;9:161-163.

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Piccirillo JF. Melatonin. Prog Brain Res. 2007;166:331-3.

Powell SR. The antioxidant properties of zinc. J Nutr. 2000;130(5S Suppl):1447S-54S.

Reiter RJ. Melatonin: clinical relevance. Best Pract Res Clin Endocrinol Metab. 2003;17(2):273-85.

Rommell T, Demisch L. Influence of chronic beta-adrenoreceptor blocker treatment on melatonin secretion and sleep quality in patients with essential hypertension. J Neural Transm [Gen Sect]. 1994;95:39-48.

Tubek S, Grzanka P, Tubek I. Role of Zinc in Hemostasis: A Review. Biol Trace Elem Res. 2007; [Epub ahead of print].

Wintergerst ES, Maggini S, Hornig DH. Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab. 2007;51(4):301-23.

Zimmermann MB, Hurrell RF. Nutritional iron deficiency. Lancet. 2007;370(9586):511-20.