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Garlic has been used as both food and medicine in many cultures for thousands of years, dating back to when the Egyptian pyramids were built. In early 18th-century France, gravediggers drank crushed garlic in wine believing it would protect them from the plague that killed many people in Europe. During both World Wars I and II, soldiers were given garlic to prevent gangrene. Today garlic is used to help prevent heart disease, including atherosclerosis or hardening of the arteries (plaque buildup in the arteries that can block the flow of blood and may lead to heart attack or stroke), high cholesterol, high blood pressure, and to boost the immune system. Garlic may also help protect against cancer.
Garlic is rich in antioxidants, which help destroy free radicals -- particles that can damage cell membranes and DNA, and may contribute to the aging process as well as the development of a number of conditions, including heart disease and cancer. Antioxidants neutralize free radicals and may reduce or even help prevent some of the damage they cause over time.
The conditions for which garlic is showing the most promise include:
Some evidence suggests that garlic may help prevent heart disease. It may slow down atherosclerosis (hardening of the arteries) and lower blood pressure slightly, between 7% and 8%. Most of the studies on high blood pressure have used a specific formulation called Kwai. One study that lasted 4 years found that people who took 900 mg daily of standardized garlic powder slowed the development of atherosclerosis. Garlic also seems to be an anticoagulant, meaning it acts as a blood-thinner, which may help prevent heart attacks and strokes.
Earlier studies found that garlic lowered high cholesterol, but more recent studies that are high quality have found no effect.
Some early evidence suggests garlic may help prevent colds. In one study, people took either garlic supplements or placebo for 12 weeks during "cold season" between November and February. Those who took garlic had fewer colds than those who took placebo. Plus, when they did get a cold, the people taking garlic saw their symptoms go away faster than those who took placebo.
Garlic may strengthen the immune system, helping the body fight diseases such as cancer. In test tubes, garlic seems to have anti-cancer activity. And population studies -- ones that follow groups of people over time -- suggest that people who eat more raw or cooked garlic are less likely to develop certain types of cancer, particularly colon and stomach cancers. In fact, researchers who reviewed 7 studies found a 30% reduction in risk of colorectal cancer among people who ate a lot of raw or cooked garlic. Garlic supplements don’t seem to have the same effect.
Garlic is a perennial that originally came from central Asia, and is now grown throughout the world. It can grow 2 feet high or more. The part of this plant used for medicine is the compound bulb. Each bulb is made up of 4 - 20 cloves, and each clove weighs about 1 gram. Garlic supplements can either be made from fresh, dried, aged, or garlic oil, and each may have different effects on the body.
What's It Made Of?
Researchers once thought that a chemical called allicin was responsible for garlic’s benefits, as well as its distinctive smell. But there are other chemicals in garlic, including some sulfur-containing compounds, that may help lower cholesterol, fight heart disease, and help prevent come cancers.
Garlic supplements are made from whole fresh garlic, dried, or freeze-dried garlic, garlic oil, and aged garlic extracts.
Not all garlic contains the same amount of active ingredients. It is important to read the label on all garlic products carefully. To get the most benefit, use standardized garlic products. Also, follow the directions of a qualified health care provider who is experienced in herbal medicine.
How to Take It
Ask your doctor before giving garlic supplements to a child. Research hasn't yet found what an effective and safe dose might be.
Whole garlic clove (as a food supplement): 2 - 4 grams per day of fresh, minced garlic clove (each clove is approximately 1 gram)
Aged garlic extract: 600 - 1,200 mg, daily in divided doses
Tablets of freeze-dried garlic: 200 mg, 2 tablets 3 times daily, standardized to 1.3% alliin or 0.6% allicin. Products may also be found standardized to contain 10 - 12 mg/Gm alliin and 4,000 mcg of total allicin potential (TAP).
Fluid extract (1:1 w/v): 4 mL, daily
Tincture (1:5 w/v): 20 mL, daily
Oil: 0.03 - 0.12 mL, 3 times daily
The use of herbs is a time-honored approach to strengthening the body and treating disease. Herbs, however, contain components that can trigger side effects and that can interact with other herbs, supplements, or medications. For these reasons, herbs should be taken with care, under the supervision of a health care provider qualified in the field of botanical medicine.
Garlic is listed as Generally Recognized as Safe (GRAS) by the U.S. Food and Drug Administration.
Side effects from garlic include upset stomach, bloating, bad breath, body odor, and a stinging sensation on the skin from handling too much fresh or dried garlic. Handling garlic may also cause skin lesions. Other, more rare side effects that have been reported by those taking garlic supplements include headache, fatigue, loss of appetite, muscle aches, dizziness described as vertigo, and allergies such as an asthmatic reaction or skin rash.
Garlic has blood-thinning properties. Too much garlic can increase your risk for bleeding during or after surgery. It may also interact with blood-thinning medications (see "Interactions").
People with ulcers or thyroid problems should ask their doctor before taking garlic.
Garlic may alter the function of certain prescription medications. If you are being treated with any of the following medications, you should not use garlic supplements without first talking to your health care provider.
Isoniazid(Nydrazid) -- This medication is used to treat tuberculosis. Garlic may lower the amount of this medication that the body absorbs, making it less effective.
Birth controlpills -- Garlic may make birth control pills less effective.
Blood-thinning medications -- Garlic may make the actions of these medications stronger, increasing the risk of bleeding. Blood-thinners include warfarin (Coumadin), clopidogrel (Plavix), and aspirin.
Medications for HIV/AIDS -- Garlic may lower blood levels of protease inhibitors, medications used to treat people with HIV. Protease inhibitors include:
Nonsteroidal anti-inflammatory drugs (NSAIDs) -- Both NSAIDs and garlic may increase the risk of bleeding. NSAIDs include ibuprofen (Advil, Motrin) and naproxen (Aleve) as well as prescription medications.
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Review Date: 1/26/2011
Reviewed By: Steven D. Ehrlich, NMD, Solutions Acupuncture, a private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network.
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