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Hawthorn

Also listed as: Crataegus laevigata; Crataegus monogyna; Crataegus oxyacantha; Hedgethorn
Table of Contents > Herbs > Hawthorn     Print

Overview
Plant Description
What's It Made Of?
Medicinial Uses and Indications
Available Forms
 
How to Take It
Precautions
Possible Interactions
Supporting Research

Overview

Hawthorn (Crataegus species ) is a small tree or shrub and a member of the rose family. It was hung over the doorway in the Middle Ages to prevent the entry of evil spirits. By the early 1800s, American doctors recognized the herb's medicinal properties and began using it to treat circulatory disorders and respiratory illnesses. Considered a "cardiotonic" herb or heart tonic, the flowers and berries of the hawthorn plant were used in traditional medicine to treat irregular heartbeat, high blood pressure, chest pain, hardening of the arteries, and heart failure. Hawthorn is commonly used to strengthen the heart.

Animal and laboratory studies report hawthorn contains active compounds with antioxidant properties. Antioxidants are substances that destroy free radicals -- damaging compounds in the body that alter cell membranes, tamper with DNA, and even cause cell death. Free radicals occur naturally in the body, but environmental toxins (including ultraviolet light, radiation, smoking, some non-prescription and prescription medicines, and air pollution) can also increase the number of these damaging particles. Free radicals are believed to contribute to the aging process (such as wrinkling) as well as the development of a number of health problems including cancer and heart disease. Antioxidants found in hawthorn may help stop some of the damage from free radicals.

Plant Description

Hawthorn is a common thorny shrub that grows up to 5 feet tall on hillsides and in sunny wooded areas throughout the world. In May its flowers bloom. They grow in small clusters, and are white, red, or pink. Small berries, called haws, sprout after the flowers. They are usually red when ripe, but they may also be black. Hawthorn leaves are shiny and grow in a variety of shapes and sizes.

What's It Made Of?

Hawthorn contains many substances that may benefit the heart. However, it appears that two substances in particular -- flavonoids and oligomeric procyanidins (OPCs) -- are most likely to contribute to hawthorn's beneficial effects on the heart. Flavonoids may help dilate blood vessels, improve blood flow, and protect the blood vessels from damage. Both flavonoids and OPCs have antioxidant effects.

The berries, leaves, and flowers of the hawthorn plant are used for medicinal purposes. The leaves and flowers are believed to contain more of the active compounds than the berries.

Medicinial Uses and Indications

Today, many health care professionals use hawthorn to help protect against heart disease and help control high blood pressure and high cholesterol.

Heart failure

Hawthorn has primarily been studied in people with heart failure (a condition in which the heart is unable to pump adequate amounts of blood to other organs in the body). Four studies conclude that hawthorn significantly improved heart function. There have found that the herb can improve a heart failure patient's ability to exercise. Patients have reported that hawthorn significantly improved symptoms of the disease (such as shortness of breath and fatigue). One study found that hawthorn extract (900 mg/day) taken for 2 months was as effective as low doses of captropril (a leading heart medication) in improving symptoms of heart failure.

A large study found that a standardized hawthorn supplement was effective in 952 patients with heart failure. The study compared conventional methods of treating heart failure (various medications) with hawthorn alone and in addition to the drugs. After 2 years, the clinical symptoms of heart failure (palpitations, breathing problems, and fatigue) decreased significantly in the patients taking the hawthorn supplement. The patients taking hawthorn also took less medications for their condition.

Atherosclerosis

Animal and laboratory studies demonstrate that this herb has antioxidant properties that help protect against the formation of plaques. The buildup of these fatty materials in the blood vessels is called atherosclerosis. Plaque buildup in the vessels supplying the heart with oxygen-rich blood may cause chest pain (angina) and heart attacks, while plaque buildup in the arteries that supply blood to the brain may result in stroke.

Chest pain

Hawthorn berry preparations have been shown to combat chest pain (angina), which is caused by low blood flow to the heart. In one early study, 60 angina patients were given either 180 mg/day of hawthorn berry-leaf-flower extract or placebo for 3 weeks. Those who received the hawthorn preparation experienced improved blood flow to the heart and were also able to exercise for longer periods of time without suffering from chest pain.

High cholesterol

Studies using rats suggest that a hawthorn tincture (made from the berries) may be a powerful agent for the removal of LDL ("bad") cholesterol from the bloodstream. The tincture of hawthorn berries also reduced the production of cholesterol in the livers of rats fed a high-cholesterol diet. More studies of hawthorn and cholesterol in people are needed.

High blood pressure

Although hawthorn has not been studied specifically in people with high blood pressure, considerable evidence supports the cardiovascular benefits of this herb. Studies suggest that hawthorn can be taken safely by people with hypertension who are also taking blood pressure medications.

A hawthorn extract was recently found to be effective for hypertension in patients with type 2 diabetes who were also taking their prescribed medicines. Patients took 1,200 mg hawthorn extract daily or placebo for 16 weeks. Those taking the hawthorn supplement had lower blood pressures than those taking the placebo.

Available Forms

Hawthorn is available in non-standardized and standardized capsules and liquid extracts, along with tinctures and solid extracts. A bitter-tasting tea can also be made from dried hawthorn leaves, flowers, and berries.

How to Take It

Pediatric

There are no known scientific reports on the pediatric use of hawthorn. Therefore, it is not currently recommended for children.

Adult

To decrease symptoms of heart failure:

  • 160 - 900 mg daily for at least 6 weeks, standardized to 2 - 3% flavonoids or 18 - 20% oligomeric procyanidins
  • 120 - 240 mg, 3 times daily for at least 6 weeks, standardized to 1.8% vitexin rhamnoside and 10%

Precautions

The use of herbs is a time-honored approach to strengthening the body and treating disease. Herbs, however, contain components that may trigger side effects and interact with other herbs, supplements, or medications. For these reasons, herbs should be taken with care, under the supervision of a health care provider qualified in the field of botanical medicine.

The American Herbal Products Association gives hawthorn a class 1 safety rating, which indicates that it is a very safe herb. Side effects are rare, but may include headache, nausea, and palpitations (a feeling of a racing heart). A recent review of 29 clinical studies with over 5,500 patients found that hawthorn was safe when used in recommended dosages. Doses found to be safe were from 160 - 1,800 mg daily and from 3 - 24 weeks in length.

Do not self-treat heart conditions without telling your doctor.

If you are pregnant or breastfeeding, do not use hawthorn.

It is extremely important for you to note any changes you feel while you are taking hawthorn. People experiencing more pain, more angina attacks, or more exhaustion while walking or exercising should stop taking hawthorn and seek immediate medical attention. Even if you don't experience any of these symptoms, see your health care provider if your condition hasn't improved after 6 weeks of hawthorn treatment. Your progress should always be monitored by your health care provider.

Possible Interactions

If you are taking prescription or non-prescription medicines, talk to your health care provider before taking herbal supplements. If you are currently being treated with any of the following medications, you should not use hawthorn without first talking to your health care provider:

Digoxin -- Hawthorn may enhance the activity of digoxin, a medication used for irregular heart rhythms.

Phenylephrine -- In a laboratory study, an alcoholic extract of hawthorn fruit counteracted the effects of phenylephrine, a medication that constricts blood vessels and is commonly found in nasal decongestant products. However, since this interaction has not been studied in humans, the relevance of this interaction to people is unknown at this time.

Supporting Research

Bahorun T, Trotin F, Pommery J, et al. Antioxidant activities of Crataegus monogyna extracts. Planta Med. 1994;60:323-328.

Blumenthal M, Goldberg A, Brinckmann J. Herbal Medicine: Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications; 2000:182-192.

Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, Ore: Eclectic Medical; 1998:82-83.

Brixius K, Willms S, Napp A, et al. Crataegus special extract WS 1442 induces an endothelium-dependent, NO-mediated vasorelaxation via eNOS-phosphorylation at serine 1177. Cardiovasc Drugs Ther. 2006;20(3):177-84.

Daniele C, Mazzanti G, Pittler MH, et al. Adverse-event profile of Crataegus spp.: a systematic review. Drug Saf. 2006;29(6):523-35.

Degenring FH, Suter A, Weber M, et al. A randomised double blind placebo controlled clinical trial of a standardised extract of fresh Crataegus berries (Crataegisan) in the treatment of patients with congestive heart failure NYHA II. Phytomedicine 2003;10(5):363-369.

Fugh-Berman A. Herbs and dietary supplements in the prevention and treatment of cardiovascular disease. Prev Cardiol. 2000;3(1):24-32.

Habs M. Prospective, comparative cohort studies and their contribution to the benefit assessments of therapeutic options: heart failure treatment with and without Hawthorn special extract WS 1442. Forsch Komplementarmed Klass Naturheilkd. 2004;11 Suppl 1:36-9.

Holubarsch CJ, Colucci WS, Meinertz T, et al. Survival and prognosis: investigation of Crataegus extract WS 1442 in congestive heart failure (SPICE)--rationale, study design and study protocol. Eur J Heart Fail. 2000;2(4):431-437.

Karch SB. The Consumer's Guide to Herbal Medicine. Hauppauge, New York: Advanced Research Press; 1999:109-111.

LaValle JB, Krinsky DL, Hawkins EB, et al. Natural Therapeutics Pocket Guide. Hudson, OH:LexiComp; 2000: 456-457.

Mashour NH, Lin GI, Frishman WH. Herbal medicine for the treatment of cardiovascular disease. Arch Intern Med. 1998;158:2225–2234.

Miller AL. Botanical influences on cardiovascular disease. Altern Med Review. 1998;3(6):422-431.

Miller L. Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med. 1998;158(20):2200–2211.

Morelli V, Zoorob RJ. Alternative therapies: Part II. Congestive heart failure and hypercholesterolemia. [Review]. Am Fam Physician. 2000;62(6):1325-1330.

Pittler MH, Schmidt K, Ernst E. Hawthorn extract for treating chronic heart failure: meta-analysis of randomized trials. Am J Med 2003;114(8):665-674.

Rajendran S, Deepalakshmi PD, Parasakthy K, et al. Effect of tincture of Crataegus on the LDL-receptor activity of hepatic plasma membrane of rats fed an atherogenic diet. Atherosclerosis. 1996;123:235-241.

Rotblatt M, Ziment I. Evidence-Based Herbal Medicine. Philadelphia, PA: Hanley & Belfus, Inc; 2002:231-235.

Rigelsky JM, Sweet BV. Hawthorn: pharmacology and therapeutic uses. Am J Health Syst Pharm. 2002;59(5):417-422.

Schultz V, Hansel R, Tyler V. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Heidelberg: Springer; 1998.

Schussler M, Holzl J, Fricke U. Myocardial effects of flavonoids from crataegus species. Arzneimittelforschung. 1995;45:842–845.

Schmidt U, Albrecht M, Schmidt S. [Effects of an herbal crataegus-camphor combination on the symptoms of cardiovascular diseases]. Arzneimittelforschung. 2000;50(7):613-619.

Tankanow R, Tamer HR, Streetman DS, et al. Interaction study between digoxin and a preparation of hawthorn (Crataegus oxyacantha). J Clin Pharmacol. 2003;43(6):637-642.

Walker AF, Marakis G, Simpson E, et al. Hypotensive effects of hawthorn for patients with diabetes taking prescription drugs: a randomised controlled trial. Br J Gen Pract. 2006;56(527):437-43.

White L, Mavor S. Kids, Herbs, Health. Loveland, Colo: Interweave Press; 1998:22.

Zapfe JG. Clinical efficacy of crataegus extract WS 1442 in congestive heart failure NYHA class II. Phytomedicine. 2001;8(4):262-266.

Review Date: 1/21/2007
Reviewed By: Ernest B. Hawkins, MS, BSPharm, RPh, Health Education Resources; and Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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Uses of this Herb
Angina
Atherosclerosis
Heart failure
Hypercholesterolemia
Hypertension
Drugs that Interact
Summary
Digoxin
Phenylephrine-containing Medications
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Herbal medicine