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Red yeast rice has been used for centuries in China as both food and medicine. It is made by fermenting a type of yeast called Monascus purpureus over red rice. In Chinese medicine, red yeast rice is used to lower cholesterol, improve blood circulation, and help digestive problems.
Red yeast rice contains chemicals that are similar to prescription statin medications. One of these, called monacolin K, has the same makeup as the drug lovastatin (Mevacor). Doctors prescribe statins to lower "bad" LDL cholesterol levels and help reduce the risk of heart disease.
Researchers aren't sure if red yeast rice lowers cholesterol because of the statin-like chemical or because of other things in red yeast rice, such as unsaturated fatty acids, isoflavones, and phytosterols. But because many red yeast rice supplements did have monacolin, the Food and Drug Administration (FDA) considered them to be drugs. Manufacturers were supposed to remove any red yeast rice products with monacolin from the market. As a result, many of the red yeast rice products you can buy may not contain monacolin. There's no way to tell, because monacolin isn't listed on the label.
Several studies have shown that red yeast rice lowers "bad" LDL cholesterol levels. High cholesterol levels raise the risk of heart disease. Red yeast (Monascus purpureus) stops the action of an enzyme in the body that helps make cholesterol.
Red yeast rice contains substances known as monacolins. One of these, monacolin K, has the same chemical makeup as lovastatin (Mevacor), a prescription drug that lowers cholesterol. Some researchers think that's why red yeast rice lowers cholesterol. But others point out that the amount of monacolin in red yeast rice is less than you would find in the prescription drug. They think there may be other substances in red yeast rice that help lower cholesterol. More research is needed.
Several studies suggest that red yeast rice reduces high cholesterol. However, most of the studies have used a formulation of red yeast rice -- Cholestin -- that is no longer available in the U.S. You can still buy Cholestin, but it no longer has any red yeast rice. The FDA requires any red yeast product that has monacolin to be taken off the market.
These studies support the claim that red yeast rice lowers cholesterol:
Asia and Chinese communities in North America use red yeast rice in powdered form as a food coloring for fish, alcoholic beverages, and cheese.
Dosage and Administration
Red yeast rice is an ingredient in several supplements advertised to promote heart health. Red yeast rice is also available in commercial preparations. One of the proprietary products most often studied was Cholestin, which contained monacolin. However, that product is no longer on the market. The current ingredients in Cholestin do not include red yeast rice.
People younger than 20 should not use red yeast rice supplements.
In Traditional Chinese Medicine, the dosage of dietary or supplemental red yeast rice is as high as 6,000 - 9,000 mg per day. But the right dose for adults may be different, depending on the form of the supplement. Most studies have used standardized extract: 600 mg, 2 - 4 times daily.
Researchers don't know whether it is safe to use red yeast rice for longer than 12 weeks.
People with liver disease and those at risk for liver disease should not take red yeast rice. Red yeast rice may affect the function in the same way prescription drugs to lower cholesterol can.
These people should not take red yeast rice: people with kidney disease, thyroid problems, or musculoskeletal disorders, or those at higher risk of cancer.
People who drink more than two alcoholic beverages a day, have a serious infection or physical condition, or have had an organ transplant should also avoid using red yeast rice.
Side effects of red yeast rice are rare but can include:
Pregnancy and Breastfeeding
Pregnant and breastfeeding women should not take red yeast rice.
People under 20 should not take red yeast rice until more research is done.
No studies have looked at the safety of red yeast rice in older adults. However, elderly people who took 1,200 mg per day of red yeast rice in an 8 week study had no major side effects.
Interactions and Depletions
Cholesterol-lowering medications -- If you take drugs to lower your cholesterol, you shouldn't take red yeast rice unless your doctor tells you to. Red yeast rice may make the effect of these drugs stronger, increasing the risk of liver damage. If you are already taking a statin or other drug to lower cholesterol, talk to your doctor before taking red yeast rice.
Anticoagulants (blood-thinners) -- Red yeast rice may increase the risk of bleeding. Blood thinners include warfarin (Coumadin), clopidogrel (Plavix), and daily aspirin.
Grapefruit juice -- If you take a statin, grapefruit and grapefruit juice can increase the amount of the drug in your blood. That can give you a greater chance of side effects and liver damage. Because red yeast rice may act like statins in the body, you should not drink grapefruit juice or eat grapefruit while taking red yeast rice.
Coenzyme Q10 -- Statins can lower the amount of coenzyme Q10 in the body. CoQ10 is very important in heart and muscle health and in energy production. Not having enough CoQ10 can cause fatigue, muscle aches and pains, and muscle damage. Red yeast rice also may lower amounts of CoQ10 in the body. Ask your doctor if you need to take CoQ10 while you are taking red yeast rice products.
Other medications -- Because it acts like a statin, red yeast rice may pose the same potential risk of liver damage that statins do, when combined with other prescription medications that also affect the liver. Some of these include:
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Review Date: 12/28/2012
Reviewed By: Steven D. Ehrlich, NMD, Solutions Acupuncture, a private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network.
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