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If you are currently being treated with any of the following medications, you should not use manganese supplements without first talking to your health care provider.
Haloperidol and other antipsychotics --There has been at least one clinical report of an interaction between haloperidol and manganese that resulted in hallucinations and behavioral changes in a person with liver disease. In addition, some experts believe that medications for schizophrenia and other forms of psychosis may worsen side effects from manganese supplements. Therefore, individuals taking haloperidol or other antipsychotic medications (particularly a class called phenothiazines, which includes chlorpromazine, mesoridazine, perphenazine, prochlorperazine, thioridazine, and trifluoperazine) should use manganese only under the supervision of a qualified health care professional.
Reserpine --Reserpine, a medication used to treat high blood pressure, may decrease manganese levels in the body.
Antacids -- Magnesium-containing antacids, such as aluminum hydroxide/magnesium hydroxide, aluminum hydroxide/magnesium carbonate, and aluminum hydroxide/magnesium trisilicate, may decrease the absorption of manganese if taken together. Take supplements containing manganese at least 1 hour before or 2 hours after taking antacids.
Laxatives -- Magnesium-containing laxatives may decrease the absorption of manganese if taken together. Take supplements containing manganese at least 1 hour before or 2 hours after taking laxatives.
Tetracycline -- The antibiotic tetracycline may reduce the absorption of manganese if taken together. Take supplements containing manganese at least 1 hour before or 2 hours after taking laxatives.