Frequency not defined. Cardiovascular: Tachycardia
Central nervous system: Drowsiness, nervousness, insomnia, transient stimulation, headache, fatigue, dizziness
Respiratory: Thickening of bronchial secretions, pharyngitis
Gastrointestinal: Appetite increase, weight gain, nausea, diarrhea, abdominal pain, xerostomia
Genitourinary: Dysuria
Neuromuscular & skeletal: Arthralgia, weakness
Miscellaneous: Diaphoresis
Triprolidine: Inhibits CYP2D6 (weak) Decreased effect of guanethidine, reserpine, methyldopa
Increased toxicity with MAO inhibitors (hypertensive crisis), sympathomimetics, CNS depressants, ethanol (sedation)
Refer to Pseudoephedrine monograph Triprolidine is a member of the propylamine (alkylamine) chemical class of H1-antagonist antihistamines. As such, it is considered to be relatively less sedating than traditional antihistamines of the ethanolamine, phenothiazine, and ethylenediamine classes of antihistamines. Triprolidine has a shorter half-life and duration of action than most of the other alkylamine antihistamines. Like all H1-antagonist antihistamines, the mechanism of action of triprolidine is believed to involve competitive blockade of H1-receptor sites resulting in the inability of histamine to combine with its receptor sites and exert its usual effects on target cells. Antihistamines do not interrupt any effects of histamine which have already occurred. Therefore, these agents are used more successfully in the prevention rather than the treatment of histamine-induced reactions.
Oral: Children:
Syrup:
4 months to 2 years: 1.25 mL 3-4 times/day
2-4 years: 2.5 mL 3-4 times/day
4-6 years: 3.75 mL 3-4 times/day
6-12 years: 5 mL every 4-6 hours; do not exceed 4 doses in 24 hours
Tablet: 1/2 every 4-6 hours; do not exceed 4 doses in 24 hours
Children >12 years and Adults:
Syrup: 10 mL every 4-6 hours; do not exceed 4 doses in 24 hours
Tablet: 1 every 4-6 hours; do not exceed 4 doses in 24 hours
Syrup: Triprolidine hydrochloride 1.25 mg and pseudoephedrine hydrochloride 30 mg per 5 mL (120 mL)
Allerfrim®: Triprolidine hydrochloride 1.25 mg and pseudoephedrine hydrochloride 30 mg per 5 mL (120 mL, 480 mL)
Allerphed®, Aprodine®: Triprolidine hydrochloride 1.25 mg and pseudoephedrine hydrochloride 30 mg per 5 mL (120 mL)
Silafed®: Triprolidine hydrochloride 1.25 mg and pseudoephedrine hydrochloride 30 mg per 5 mL (120 mL, 240 mL)
Tablet (Actifed® Cold and Allergy, Allerfrim®, Aphedrid™, Aprodine®, Genac®, Tri-Sudo®, Uni-Fed®): Triprolidine hydrochloride 2.5 mg and pseudoephedrine hydrochloride 60 mg
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