Tropical sprue is a condition seen in residents of, or visitors to, tropical areas. It impairs the absorption of nutrients from the intestines, causing malabsorption.

See also: Celiac disease - sprue

This disease is caused by inflammation of, and damage to the small intestine due to having too much of certain types of bacteria in the intestines.

Risk factors are:

• Living in the tropics
• Long periods of travel to tropical destinations

• Abdominal cramps
• Diarrhea, worse on high-fat diet
• Excessive gas (flatus)
• Indigestion
• Irritability
• Muscle cramps
• Numbness
• Paleness
• Weight loss

• Bone density test
• Complete blood count (CBC)
• Comprehensive metabolic panel
• Enteroscopy
• Folate level (serum)
• Iron level (serum)
• Stool examination for bacteria and parasites
• Upper endoscopy
• Upper GI series
• Vitamin B12 level (serum)
• Vitamin D level

Treatment begins with plenty of fluids and electrolytes. Replacement of folate, iron, vitamin B12, and other nutrients may also be needed. Antibiotic therapy with tetracycline or another broad-spectrum antibiotic is given at the beginning of treatment.

Oral tetracycline is usually not prescribed for children until after all of their permanent teeth have appeared, because it can permanently discolor teeth that are still forming. However, other antibiotics are available.

The outcome is good with treatment.

Vitamin and mineral deficiencies are common complications.

In children, sprue leads to:

• Delay in the maturing of bones (skeletal maturation)
• Growth failure

Call your health care provider if:

• Tropical sprue symptoms get worse or do not improve with treatment
• You develop new symptoms
• You have diarrhea or other symptoms of this disorder for a long period of time, especially after spending time in the tropics

Other than avoiding living in or traveling to tropical climates, there is no known prevention for tropical sprue.

Semrad CE. Approach to the patient with diarrhea and malabsorption. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 142.