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Scleroderma is a group of diseases that causes skin and sometimes internal organs to become hard and tight. In fact, the word scleroderma actually means "hard skin." It happens when the body makes too much collagen, the protein that makes up connective tissues.
Localized scleroderma usually only affects the skin on the hands and face. Systemic scleroderma is more serious and affects connective tissue in many parts of your body, including internal organs.
Scleroderma is considered an autoimmune disease, meaning that the immune system mistakenly attacks the body's own tissues. According to the Scleroderma Foundation, about 300,000 people in the United States have the condition. It is more common in women than men.
Signs and Symptoms
Symptoms of scleroderma may include the following:
Doctors believe scleroderma is caused by the immune system mistakenly attacking the body's own tissues. The immune system attack causes inflammation and triggers the body to make too much collagen. Too much collagen causes the skin, and sometimes the internal organs, to become hard and tight. Researchers aren't sure what triggers this autoimmune response. Both genetics and environment may play a role.
These factors may increase the risk of scleroderma:
It isn't always easy to diagnose scleroderma. You may need to see both a rheumatologist (arthritis specialist) and a dermatologist (skin specialist). The doctor will do a physical examination and feel your skin to check for thickened and hardened areas. The doctor may also press affected tendons and joints and do the following:
Many early scleroderma symptoms are like those of other connective-tissue diseases, such as rheumatoid arthritis, lupus, and polymyositis. When someone has more than one of these diseases, it is called mixed connective-tissue disease.
Although no one knows how to prevent scleroderma, you can take steps to avoid getting infections when you have scleroderma. Your doctor may recommend:
There is no cure for scleroderma. Medications can treat symptoms and prevent complications. Making changes to your lifestyle and diet can make living with the disease easier.
These simple steps may help improve quality of life:
Localized scleroderma often is treated with moisturizers or steroid creams. Oral medications such as minocycline (Minocin or Dynacin) may also be used to stop localized scleroderma from getting worse if it involves a large area of the body, such as an entire arm or leg.
Systemic scleroderma may be treated with medications that improve circulation, reduce heartburn, preserve kidney function, and control high blood pressure. Some medications a doctor may prescribe for scleroderma include:
Surgery and Other Procedures
When symptoms of scleroderma become very severe, doctors may recommend the following procedures:
Nutrition and Dietary Supplements
People with scleroderma may not get enough vitamins and minerals in their diet, especially if there is damage to their digestive system. Your doctor may suggest you take a supplement. Always tell your doctor about the herbs and supplements you are using or considering using.
These general nutritional tips are good for your overall health, especially if you have a long-lasting disease:
Your doctor may recommend taking a multivitamin daily that has the antioxidant vitamins A, C, E, the B-complex vitamins, and trace minerals such as magnesium, calcium, zinc and selenium.
These supplements may help reduce some symptoms:
Herbs may strengthen and tone the body's systems. As with any therapy, you should work with your health care provider before starting any treatment.
Very few studies have been done using these herbs to treat scleroderma. Ask your doctor before taking any of them.
A few studies suggest that acupuncture may improve blood flow in the hands and fingers, help heal fingertip ulcers, and maybe reduce the formation of fibrous tissue. It may also relieve pain.
Massage and Physical Therapy
Research suggests that massage may help improve circulation. More research is needed to know whether massage works for scleroderma.
Biofeedback may help some people with scleroderma better control the temperature in their hands and feet, although studies are mixed. Other mind-body techniques such as counseling, meditation, and emotional freedom technique (EFT) may help.
Prognosis and Complications
Possible complications include the following:
The prognosis for people with scleroderma depends a lot on which form of the disease they have. For example:
Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006;5(6):493-506.
Fauci AS, Braunwald E, Hauser SL, et al, eds. Harrison's Principles of Internal Medicine. 17th ed. New York, NY: McGraw-Hill; 2008.
Frech TM, Khanna D, Maranian P, Frech EJ, Sawitzke AD, Murtaugh MA. Probiotics for the treatment of systemic sclerosis-associated gastrointestinal bloating/ distention. Clin Exp Rheumatol. 2011 Mar-Apr;29(2 Suppl 65):S22-5.
Hale LP, Greer PK, Trinh CT, James CL. Proteinase activity and stability of natural bromelain preparations. Int Immunopharmacol. 2005;5(4):783-93.
Hunnicutt SE, Grady J, McNearney TA. Complementary and alternative medicine use was associated with higher perceived physical and mental functioning in early systemic sclerosis. Explore (NY). 2008 Jul-Aug;4(4):259-63.
Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr. 2002;21(6):495-505.
Wang HK. The therapeutic potential of flavonoids. Expert Opin Investig Drugs. 2000;9(9):2103-19.
Wollina U, Abdel-Naser MB, Mani R. A review of the microcirculation in skin in patients with chronic venous insufficiency: the problem and the evidence available for therapeutic options. Int J Low Extrem Wounds. 2006;5(3):169-80.
Yoon JH, Baek SJ. Molecular targets of dietary polyphenols with anti-inflammatory properties. Yonsei Med J. 2005;46(5):585-96.
Review Date: 12/17/2012
Reviewed By: Steven D. Ehrlich, NMD, Solutions Acupuncture, a private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network.
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