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Anticonvulsant medications - miscellaneous

Index > Depletions > Anticonvulsant medications - miscellaneous     Print

Medications
Depletions
Editorial Note
Supporting Research

Medications

  • Carbamazepine
    • Carbatrol
    • Epitol
    • Tegretol
    • Tegretol-XR

Depletions

Calcium

Osteoporosis (bone loss) is the main disease that comes from not getting enough calcium. Lack of calcium also may be linked with bone pain and spinal problems. Low levels can also cause muscle cramps, irregular heartbeat, and depression.

Vitamin B9 (Folic Acid)

Low levels of folic acid have been linked to anemia, heart disease, and birth defects. Symptoms may include fatigue, mouth sores, swollen tongue, and poor growth.

Vitamin H (Biotin)

Low levels of biotin are linked with dry skin, hair that breaks easily, hair loss, depression or altered mental status, nausea and vomiting, loss of appetite, and muscle pain.

Vitamin D

Vitamin D works with calcium to keep bones strong. Low levels of vitamin D can cause rickets in children and osteomalacia in adults, conditions where the bones get soft and thin. It can also raise the risk of osteoporosis.

Editorial Note

The information presented here covers some of the nutrients that may be lowered when you take certain medications. The signs and symptoms listed can be caused by other conditions. So if you have these signs and symptoms, it doesn't always mean you have low levels of these nutrients. Many things affect the level of nutrients, including your medical history, diet, and lifestyle, as well as how long you have been taking the medication. Please talk with your health care provider. He or she can best address your health care needs and see if you are at risk for low levels of any nutrients.

Supporting Research

Ames BN. Micronutrient deficiencies: A major cause of DNA damage. Ann NY Acad Sci. 2000;889:87-106.

Attilakos A, Papakonstantinou E, Schulpis K, Voudris K, Katsarou E, Mastroyianni S, Garoufi A. Early effect of sodium valproate and carbamazepine monotherapy on homocysteine metabolism in children with epilepsy. Epilepsy Res. 2006;71(2-3):229-32.

Deda G, Caksen H, Içagasioglu D.Effect of long-term carbamazepine therapy on serum lipids, vitamin B12 and folic acid levels in children. J Pediatr Endocrinol Metab. 2003;16(2):193-6.

Kjær D, Horvath-Puhó E, Christensen J, Vestergaard M, Czeizel AE, Sørensen HT, Olsen J. Antiepileptic drug use, folic acid supplementation, and congenital abnormalities: a population-based case-control study. BJOG. 2007; [Epub ahead of print].

Kumar N. Neurologic Presentations of Nutritional Deficiencies. Neurologic Clinics. 2010; 26(1).

Moretti R, Torre P, Antonello RM, Cazzato G, Cattaruzza T, Scapicchio PL. Vitamin B12 and folate depletion: clinical evidence in a neurological population. Neurologist. 2004;10(6):338-43.

Pelton R, LaValle J, Hawkins EB, et al. Drug Induced Nutrient Depletion Handbook. Hudson, OH:LexiComp, Inc.;2001:390-395.

Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol. 2006;5(11):949-60.

Review Date: 9/29/2012
Reviewed By: Steven D. Ehrlich, NMD, Solutions Acupuncture, a private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed HealthCare Network.
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